Asking is fundamental to the evidence-based decision-making process. A well-built question includes four parts, referred to as PICO that identify the patient problem or population (P), intervention (I), comparison (C) and outcome (O).
Example: How do alternative breast cancer treatments improve the quality of life for young adult females?
P = young adult females with breast cancer
I = alternative therapies
C = patients who don't use alternative therapies
O = quality of life improvement